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New Coronavirus protein reveals drug target

 

A potential drug target has been identified in a newly mapped protein of SARS-CoV-2, the virus that causes coronavirus disease 2019 (COVID-19).

 

RCC2 is a novel p53 target in suppressing metastasis

 

 

 

 

 

 

 

 

 

 

 

 

Structure of the Nsp15 hexamer.

 

Crystal structure of Nsp15 endoribonuclease NendoU from SARS-CoV-2

Youngchang Kim, Robert Jedrzejczak, Natalia I. Maltseva, Michael Endres, Adam Godzik, Karolina Michalska, Andrzej Joachimiak.

Protein Sci. 2020 Apr 17. doi: 10.1002/pro.3873. [Epub ahead of print]

PMID: 32304108

 

 

PDB: 6VWW, 6W01

 

APS Coronavirus Research in the Media Spotlight

 

 

Users should check the APS website for updated information on site access in response to

COVID-19 outbreak.

 

Current Beamline Statistics:

APS PDB Depositions from BioSync

SBC Sector 19 2018 2019 2020 TOTAL
ID BM ID BM ID BM
PDB Depositions 175 44 145 45 68 14 5792
 

 

SBC News:

SBC Highlights featured by ANL, APS and Media

SBC Highlights previously featured by SBC

 
 

Announcements:

SBC Staff Hosting

 

The SBC Staff Host will be available for User support from 8:00am to 10:00pm (CST), Monday-Friday.  If you need weekend assistance, you will need to make special arrangements with the host prior to beamtime. 

 

Job Opening: Postdoctoral Appointee

Argonne National Laboratory seeks a postdoctoral researcher to join the Structural Biology Center (SBC) at the Advanced Photon Source (APS) to develop methods in crystallography and other techniques. Building on our expertise in high resolution de novo structure determination, serial crystallography and a long history of cutting edge experiments, we would like to bring the next generation of experiments to the SBC general user program. The postdoctoral fellow will develop hardware and software to analyze molecular changes of structures as diffraction data is collected and processed autonomously, will create the experimental scope, source samples, collect and analyze data.

 

Requisition # 407010

Apply Here

 

 

Student Training

SBC offers applications for remote faculty supervised training of students in remote data collection on 19BM beamline.  SBC can provide standard protein crystals (lysozyme, thaumatin) for data collection. SBC resources for data collection, processing and structure determination will be available. The SBC staff will assist in training. This training will help the next generation of synchrotron light source users and scientists learn software and strategies for data collection, data processing, and structure determination.  Please contact mficner@anl.gov for more information.

 

 

Beamlines

 

Upgraded ADSC 315r Detector on 19-BM with double the area size and atomic resolution.

 

New Oxford Cryostream 800 Series now available on both 19-ID and 19-BM.

 

Rigaku Actor Robot, with heated end effector, upgraded on 19-ID.

 

Sample-mounting pins must be 18mm in length and use either SSRL or ALS bases.

 

 

ESAF Requirements

 

When completing your Experimental Safety Approval Form (ESAF), please include the following in your experimental description:

  • Full name of sample - NOT just the acronym!
  • Source of protein (eg. over-produced in e. coli, purchased from vendor, etc.)
  • Biosafety Level of sample

 

APS requests the ESAF be submitted at least seven days prior to your scheduled beamtime.

 

 

Web Site:

If you have any suggestions or comments, e-mail us.

 

Rapid Access Beamtime Available:

SBC Beamtime Request System

The SBC Beamtime Request System allows users to view available beamtime on 19-ID and 19-BM, and to submit a request for rapid beamtime allocation.

Beamtime is available to the research community via a peer reviewed proposal system; it is supported by the U.S. Department of Energy, Office of Biological and Environmental Research.

 

APS Publications Database:

Publications Total
SBC-CAT Publication List: 19-ID 1771
SBC-CAT Publication List: 19-BM 599
APS Publications Database

SBC Acknowlegement:

Results shown in this report are derived from work performed at Argonne National Laboratory (ANL), Structural Biology Center (SBC) at the Advanced Photon Source (APS), under U.S. Department of Energy, Office of Biological and Environmental Research contract DE-AC02-06CH11357."

 

 

Use of the APCF:

APS Sector 84 at the APCF operates the high-throughput protein structure determination and characterization pipeline as a resource for Biology Community. The structure determination platform is well established and it combines technologies, robotics and expertise for gene cloning, protein production, crystallization, and biochemical and biophysical characterization. Data collection and structure determination will be done using SBC and other MX beamlines at the APS. The APCF maintains a bank of microbial genomic DNA, protein expression vectors and clones, variety of proteomics and computational software tools and project databases. The APCF will host and train visiting scientists.

 

To apply: Sumbit an ESAF for Sector 84.

 

APCF Acknowlegement: Access to Sector 84 laboratories at the Advanced Protein Characterization Facility (APCF) was possible through funding provided by NIH grant GM115586 and DOE contract DE-AC02-06CH11357.

 

For more information please contact

Michelle Radford or Paula Bulaon.

 

 

SBC Beamline Phone Numbers:

Phone Location Number
19-ID Beamline Control Station 630-252-9823
19-ID Beamline Cordless Phone 630-252-0569
19-ID Beamline Inside D-Hutch 630-252-1819
 
19-BM Beamline Control Station 630-252-9833
19-BM Beamline Cordless Phone 630-252-0568
19-BM Beamline Inside D-Hutch 630-252-1719