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SARS CoV-2 Research at SBC







SARS-CoV-2 ADP-ribose phosphatase




Advanced Photon Source at the Heart of COVID-19 Research



How Scientists Around the Country are Using the APS to Fight COVID-19


A potent antibody taken from a surviving patient could be the key to unlocking new COVID-19 treatments.


Mapping the Structure of a Potent Antibody against the Coronavirus



RCC2 is a novel p53 target in suppressing metastasis

New Coronavirus protein reveals drug target


A potential drug target has been identified in a newly mapped protein of SARS-CoV-2, the virus that causes coronavirus disease 2019 (COVID-19)


Structure of the Nsp15 hexamer.


"Crystal structure of Nsp15 endoribonuclease NendoU from SARS-CoV-2," Youngchang Kim, Robert Jedrzejczak, Natalia I. Maltseva, Mateusz Wilamowski, Michael Endres, Adam Godzik, Karolina Michalska, Andrzej Joachimiak, Protein Sci. 29 (7), 1596-1605 (2020). DOI: 10.1002/pro.3873



Publication Highlights

"Room-temperature X-ray crystallography reveals the oxidation and reactivity of cysteine residues in SARS-CoV-2 3CL Mpro: insights into enzyme mechanism and drug design". Kneller DW, Phillips G, O'Neill HM, Tan K, Joachimiak A, Coates L, Kovalevsky A.Kneller DW, et al. IUCrJ. 2020 Sep 21;7(Pt 6):10.1107/S2052252520012634. doi: 10.1107/S2052252520012634. Online ahead of print.IUCrJ. 2020. PMID: 33063790


"Distinct B cell subsets give rise to antigen-specific antibody responses against SARS-CoV-2. " Wilson P, Stamper C, Dugan H, Li L, Asby N, Halfmann P, Guthmiller J, Zheng NY, Huang M, Stovicek O, Wang J, Madariaga ML, Shanmugarajah K, Jansen M, Amanat F, Stewart I, Changrob S, Utset H, Huang J, Nelson C, Dai YN, Hall P, Jedrzejczak R, Joachimiak A, Krammer F, Fremont D, Kawaoka Y.Wilson P, et al. Res Sq. 2020 Sep doi: 10.21203/ Preprint.Res Sq. 2020. PMID: 32995763


"Crystal structures of SARS-CoV-2 ADP-ribose phosphatase: from the apo form to ligand complexes." Michalska K, Kim Y, Jedrzejczak R, Maltseva NI, Stols L, Endres M, Joachimiak A.Michalska K, et al.  IUCrJ. 2020 Jul 17;7(Pt 5):814-824. doi: 10.1107/S2052252520009653. eCollection 2020 Sep 1.IUCrJ. 2020. PMID: 32939273


"SARS-CoV-2 infection severity is linked to superior humoral immunity against the spike." Guthmiller JJ, Stovicek O, Wang J, Changrob S, Li L, Halfmann P, Zheng NY, Utset H, Stamper CT, Dugan HL, Miller WD, Huang M, Dai YN, Nelson CA, Hall PD, Jansen M, Shanmugarajah K, Donington JS, Krammer F, Fremont D, Joachimiak A, Kawaoka Y, Tesic V, Madariaga ML, Wilson PC.Guthmiller JJ, et al. bioRxiv. 2020 Sep 13:2020.09.12.294066. doi: 10.1101/2020.09.12.294066. Preprint.bioRxiv. 2020. PMID: 32935099


Structural basis for potent neutralization of SARS-CoV-2 and role of antibody affinity maturation,"Nicholas K. Hurlburt, Emilie Seydoux, Yu-Hsin Wan, Venkata Viswanadh Edara, Andrew B. Stuart, Junli Feng, Mehul S. Suthar, Andrew T. McGuire, Leonidas Stamatatos, Marie Pancera, " Nat. Commun. 11, 5413 (2020). DOI: 10.1038/s41467-020-19231-9


Boceprevir, GC-376, and calpain inhibitors II, XII inhibit SARS-CoV-2 viral replication by targeting the viral main protease,"Chunlong Ma, Michael Dominic Sacco, Brett Hurst, Julia Alma Townsend, Yanmei Hu, Tommy Szeto, Xiujun Zhang, Bart Tarbet, Michael Thomas Marty, Yu Chen, Jun Wang, " Cell Res. 30, 678-692 (2020). DOI: 10.1038/s41422-020-0356-z


SBC & APS Coronavirus Research in the Media Spotlight


Users should check the APS website for updated information on site access in response to

COVID-19 outbreak.


Current Beamline Statistics:

APS PDB Depositions from BioSync

SBC Sector 19 2018 2019 2020 TOTAL
PDB Depositions 176 44 182 54 123 21 5901


SBC News:

SBC News and Highlights

SBC Highlights featured by SBC 2018-2015



SBC Staff Hosting


The SBC Staff Host will be available for User support from 8:00am to 10:00pm (CST), Monday-Friday.  If you need weekend assistance, you will need to make special arrangements with the host prior to beamtime. 


Student Training

SBC offers applications for remote faculty supervised training of students in remote data collection on 19BM beamline.  SBC can provide standard protein crystals (lysozyme, thaumatin) for data collection. SBC resources for data collection, processing and structure determination will be available. The SBC staff will assist in training. This training will help the next generation of synchrotron light source users and scientists learn software and strategies for data collection, data processing, and structure determination.  Please contact for more information.





Upgraded ADSC 315r Detector on 19-BM with double the area size and atomic resolution.


New Oxford Cryostream 800 Series now available on both 19-ID and 19-BM.


Rigaku Actor Robot, with heated end effector, upgraded on 19-ID.


Sample-mounting pins must be 18mm in length and use either SSRL or ALS bases.



ESAF Requirements


When completing your Experimental Safety Approval Form (ESAF), please include the following in your experimental description:

  • Full name of sample - NOT just the acronym!
  • Source of protein (eg. over-produced in e. coli, purchased from vendor, etc.)
  • Biosafety Level of sample


APS requests the ESAF be submitted at least 7 days prior to your scheduled beamtime.



Web Site:

If you have any suggestions or comments, e-mail us.


Rapid Access Beamtime Available:

SBC Beamtime Request System

The SBC Beamtime Request System allows users to view available beamtime on 19-ID and 19-BM, and to submit a request for rapid beamtime allocation.

Beamtime is available to the research community via a peer reviewed proposal system; it is supported by the U.S. Department of Energy, Office of Biological and Environmental Research.


APS Publications Database:

Publications Total
SBC-CAT Publication List: 19-ID 1803
SBC-CAT Publication List: 19-BM 603
APS Publications Database

SBC Acknowlegement:

Results shown in this report are derived from work performed at Argonne National Laboratory (ANL), Structural Biology Center (SBC) at the Advanced Photon Source (APS), under U.S. Department of Energy, Office of Biological and Environmental Research contract DE-AC02-06CH11357."



Use of the APCF:

APS Sector 84 at the APCF operates the high-throughput protein structure determination and characterization pipeline as a resource for Biology Community. The structure determination platform is well established and it combines technologies, robotics and expertise for gene cloning, protein production, crystallization, and biochemical and biophysical characterization. Data collection and structure determination will be done using SBC and other MX beamlines at the APS. The APCF maintains a bank of microbial genomic DNA, protein expression vectors and clones, variety of proteomics and computational software tools and project databases. The APCF will host and train visiting scientists.


To apply: Sumbit an ESAF for Sector 84.


APCF Acknowlegement: Access to Sector 84 laboratories at the Advanced Protein Characterization Facility (APCF) was possible through funding provided by NIH grant GM115586 and DOE contract DE-AC02-06CH11357.


For more information please contact

Michelle Radford or Paula Bulaon.



SBC Beamline Phone Numbers:

Phone Location Number
19-ID Beamline Control Station 630-252-9823
19-ID Beamline Cordless Phone 630-252-0569
19-ID Beamline Inside D-Hutch 630-252-1819
19-BM Beamline Control Station 630-252-9833
19-BM Beamline Cordless Phone 630-252-0568
19-BM Beamline Inside D-Hutch 630-252-1719