Chemistry experts discover how key enzyme in amino acid metabolism works

SEPTEMBER 3, 2020 — UTSA researchers have discovered how 3-hydroxyanthranilate-3,4-dioxygenase, an enzyme known as HAO that is involved in the breakdown of tryptophan and the biosynthesis of nicotinamide adenine dinucleotide, prevents the overproduction of quinolinic acid, which is associated with neurodegenerative diseases.