Fine-Tuning Breast Cancer Treatment to Overcome Drug Resistance: Recent findings based on data from studies at the U.S. Department of Energy’s Advanced Photon Source may lead to the design of new second-line breast cancer treatments or to strategies for fine-tuning the sequencing of treatments to optimize the characteristics of different drugs to avoid resistance mechanisms.
New Structures of Malaria Fighting Antibodies Lead to New Options for Vaccine Development: We are faced with the simple fact that COVID is now just one of the many endemic infectious diseases that we live with―and it may not be the most prevalent. Researchers conducting experiments at the U.S. Department of Energy’s Advanced Photon Source are making significant strides in understanding the structures, binding sites, and interactions of malaria-fighting antibodies. The insights gained through this research may lead to new, more effective vaccines, with improved longevity and efficacy.
Despite the fact that between 10% and 40% of Crimean-Congo hemorrhagic fever cases are fatal, there is little known about the mechanism that the body uses to counteract the virus and the structure of the neutralizing antibodies involved in this process. Researcher at the U.S. Department of Energy’s Advanced Photon Source, the European Synchrotron Radiation Facility, and the French SOLEIL synchrotron provide new insights for protection against this contagious and often fatal virus.
Scientists from three U.S. Department of Energy (DOE) national laboratories have published research at those DOE laboratories that – alongside other recent, complementary studies of coronavirus proteins and genetics – represents the first step toward developing treatments for COVID-19.
Masitinib, an existing drug used to treat tumors in animals, may be an effective treatment against many types of coronaviruses, including the one that causes COVID-19. (Image by Shutterstock/Cagkan Sayin.)
In two recent studies, researchers using the Advanced Photon Source have identified existing drugs that may inhibit the virus that causes COVID-19.
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